The effect of ouabain on basal and thyroid hormone-stimulated muscle oxygen consumption |
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| Authors: | G M Wardlaw |
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| Affiliation: | 1. Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt;2. Negida academy LLC, Arlington, MA, USA;3. Department of Surgery, College of medicine, Ninevah University, Mosul, Iraq;1. Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia;2. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia |
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| Abstract: | In vivo triiodothyronine treatment (T3) increased soleus muscle oxygen consumption (QO2) when measured in vitro. Ouabain significantly decreased T3-induced muscle QO2, but not basal muscle QO2. Ouabain-sensitive metabolic processes in muscle, which essentially represents Na-K-ATPase activity, accounted for approximately 85% of the increased energy utilization by muscles that was caused by T3 treatment. |
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