| SARS-CoV对幼年和成年布氏田鼠的感染研究 |
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| 引用本文： | 高虹,彭景楩,邓巍,施大钊,鲍琳林,王德华,张兵林,秦川,张知彬.SARS-CoV对幼年和成年布氏田鼠的感染研究[J].中国实验动物学报,2005(Z1). |
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| 作者姓名： | 高虹 彭景楩 邓巍 施大钊 鲍琳林 王德华 张兵林 秦川 张知彬 |
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| 作者单位： | 中国医学科学院实验动物研究所中国协和医科大学实验动物学部，中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室，计划生育生殖生物学国家重点实验室，中国医学科学院实验动物研究所中国协和医科大学实验动物学部，中国农业大学，中国医学科学院实验动物研究所中国协和医科大学实验动物学部，中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室，计划生育生殖生物学国家重点实验室，中国医学科学院实验动物研究所中国协和医科大学实验动物学部，中国医学科学院实验动物研究所中国协和医科大学实验动物学部，中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室，计划生育生殖生物学国家重点实验室 北京100021，北京100080，北京100021，北京100094，北京100021，北京100080，北京100021，北京100021，北京100080 |
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| 摘 要： | 采用鼻腔喷雾法(CCID50=105.7)研究了SARS冠状病毒(SARS-CoV)对成年和幼年布氏田鼠的感染效果.成年动物攻毒后出现死亡,表现为口鼻有出血,肠道出血;肺组织呈出血性间质性肺炎改变,肝、脾、肾、胰腺组织均呈淤血性改变;存活动物肺组织呈间质性肺炎,局灶出血及肺气肿改变,其他脏器未见明显病变.幼年动物攻毒后未见死亡但行动较为迟缓,主要脏器未见明显异常;早期肺组织有局限性肺炎改变,且病毒分离为阳性;同居对照组的一只动物有肺组织局灶性肺炎.结果表明,SARS-CoV可以很强地感染布氏田鼠;成年布氏田鼠比幼年动物对SARS-CoV更敏感;布氏田鼠有望成为一种比较理想的小型SARS动物模型。
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| 关 键 词： | 严重急性呼吸系统综合症 动物模型 间质性肺炎 布氏田鼠 |
Infection of SARS CoV on juvenile and adult Brandt's Vole Microtus brandtii |
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| GAO Hong,PENG Jingpian,DENG Wei,SHI Dazhao,BAO Linlin,WANG Dehua,ZHANG Binglin,QIN Chuan & ZHANG Zhibin . State Key Laboratory of Integrated Management on Pest Insects and Rodents,State Key Laboratory ofReproductive Biology.Infection of SARS CoV on juvenile and adult Brandt''''s Vole Microtus brandtii[J].Acta Laboratorium Animalis Scientia Sinica,2005(Z1). |
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| Authors: | GAO Hong PENG Jingpian DENG Wei SHI Dazhao BAO Linlin WANG Dehua ZHANG Binglin QIN Chuan & ZHANG Zhibin State Key Laboratory of Integrated Management on Pest Insects and Rodents State Key Laboratory ofReproductive Biology |
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| Institution: | GAO Hong2,PENG Jingpian1,DENG Wei3,SHI Dazhao3,BAO Linlin2,WANG Dehua1,ZHANG Binglin2,QIN Chuan2 & ZHANG Zhibin1 1. State Key Laboratory of Integrated Management on Pest Insects and Rodents,State Key Laboratory ofReproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100080,China,2. Institute of Laboratory Animals Science,Chinese Academy of Medical Sciences |
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| Abstract: | We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID_ 50 is 105.7). SARS virus caused serious deaths in adults. The death adults showed hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults showed local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research. |
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| Keywords: | SARS-CoV animal model pneumonia Brandt's Vole |
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