Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides. |
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| Authors: | C Chong-Cerrillo M E Selsted E M Peterson L M de la Maza |
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| Institution: | Department of Pathology, Medical Sciences, Room D440, University of California, Irvine, CA 92697-4800, USA. |
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| Abstract: | Four antimicrobial peptides, protegrin-1, RTD-1, cryptdin-4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In general, protegrin-1 was found to have the strongest anti-chlamydial activity. Overall, of the three serovars tested, L2 was the most susceptible while MoPn was the most resistant to these peptides. |
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