Rugulosuvines A and B,Diketopiperazine Alkaloids of Penicillium rugulosumand Penicillium piscariumFungi |
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| Authors: | Kozlovsky A G Adanin V M Dahse H M Grafe U |
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| Institution: | (1) Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, prosp. Nauki 5, Pushchino, Moscow oblast, 142290, Russia;(2) Hans Knoll Institute of Natural Product Research, D-07745 Jena, Germany |
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| Abstract: | Two diketopiperazine alkaloids, rugulosuvines A and B (tryptophan and phenylalanine are their precursors), were isolated and purified from a culture liquid of Penicillium rugulosumVKM F-352 and Penicillium piscariumVKM F-325 fungi. Physical and physicochemical studies showed the absolute structure of rugulosuvine A. The absolute structure of rugulosuvine B was demonstrated to be identical to that of rugulosuvine A. |
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