Effects of Anticonvulsants on the Formation of γ-Hydroxybutyrate from γ-Aminobutyrate in Rat Brain |
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| Authors: | Susan R. Whittle Anthony J. Turner |
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| Affiliation: | Department of Biochemistry, University of Leeds, Leeds, U.K. |
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| Abstract: | ![]()
Abstract: The conversion of γ-aminobutyrate (GABA) via succinic semialdehyde to γ-hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde. |
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| Keywords: | Aldehyde reductase Anticonvulsants Sodium valproate γ-Hydroxybutyrate GABA metabolism Succinic semialdehyde |
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