Stabilization of casein mRNA by prolactin and glucocorticoids. |
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Authors: | L M Houdebine E Devinoy C Delouis |
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Institution: | Laboratoire de Physiologie de la Lactation, Institut National de la Recherche Agronomique, C.N.R.Z., 78350 Jouy-en-Josas, France |
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Abstract: | Prolactin injected into pseudopregnant rabbits led to a parallel enhancement of casein synthesis and casein mRNA concentration. When this stimulation was followed by a withdrawal of prolactin obtained by injections of bromocriptine, the rate of casein synthesis progressively diminished. In the presence of endogenous prolactin after the initial stimulation, the decline of casein synthesis was delayed. Hydrocortisone acetate injected with bromocriptine after the initial stimulation by prolactin was able to maintain a high rate of casein synthesis. Measurements of casein mRNA concentration by hybridization with casein cDNA indicated that in all cases the amount of casein mRNA was correlated with the magnitude of casein synthesis. This suggests that the lactogenic hormones, prolactin and glucocorticoids, which were previously demonstrated to be responsible for the enhancement of casein mRNA concentration are involved in their stabilization. |
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Keywords: | To whom all correspondence should be addressed |
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