Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases |
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| Authors: | Haiyan Wang Yanshan Zheng Shaoheng He |
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| Affiliation: | (1) Allergy and Inflammation Research Institute, the Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, 515031, China |
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| Abstract: | ![]()
Background Hypersecretion of cytokines and serine proteinases has been observed in asthma. Since protease-activated receptors (PARs) are receptors of several serine proteinases and airway epithelial cells are a major source of cytokines, the influence of serine proteinases and PARs on interleukin (IL)-8 secretion and gene expression in cultured A549 cells was examined. |
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