|
|||||
|
|
| 党参合剂对多器官功能障碍综合征菌群失调及免疫功能的调整 | |
| 引用本文： | 王茉琳,李晓光,王建杰,张涛,杨景云.党参合剂对多器官功能障碍综合征菌群失调及免疫功能的调整[J].中国微生态学杂志,2011,23(7):586-588. |
| 作者姓名： | 王茉琳 李晓光 王建杰 张涛 杨景云 |
| 作者单位： | 1. 佳木斯大学,基础医学院免疫教研室,黑龙江,佳木斯,154007 2. 佳木斯大学附属第三医院,黑龙江,佳木斯,154002 3. 佳木斯大学,微生态学研究中心,黑龙江,佳木斯,154007 |
| 基金项目： | 国家重点基础研究发展计划(973计划)(2007CB513008) |
| 摘 要： | 目的研究党参合剂通过调整菌群失调,修复肠屏障功能,控制细菌、内毒素易位,提高机体免疫力,对多器官功能障碍大鼠肠源性感染及内毒素血症(IETM)进行防治。方法采用肠缺血再灌注的方法制造多器官功能障碍综合征(MODS)模型,分别以党参合剂、丽珠肠乐对动物进行灌胃治疗。取肠内容物、肝、脾、肠系膜淋巴结,门静脉血,分别做无菌培养,内毒素及sIgA的测定。结果各治疗组通过扶植肠道有益菌、抑制有害菌的生长繁殖并促进其排泄,保护肠黏膜屏障,明显降低了细菌易位,控制内毒素血症,改善了相关免疫指标。结论党参合剂从调整微生态失调的角度来防治MODS取得较好效果,优于丽珠肠乐。 |
| 关 键 词： | 党参合剂 肠道菌群 细菌易位 多器官功能障碍 |
Radix codonopsis mixture treats multiple organ dysfunction syndrome by adjusting intestinal tract dysbacteriosis and immunologic function |
|
| WANG Mo-lin,LI Xiao-guang,WANG Jian-jie,ZHANG Tao,YANG Jing-yun.Radix codonopsis mixture treats multiple organ dysfunction syndrome by adjusting intestinal tract dysbacteriosis and immunologic function[J].Chinese Journal of Microecology,2011,23(7):586-588. | |
| Authors: | WANG Mo-lin LI Xiao-guang WANG Jian-jie ZHANG Tao YANG Jing-yun |
| Institution: | WANG Mo-lin1,LI Xiao-guang2,WANG Jian-jie1,ZHANG Tao1,YANG Jing-yun3(1.Basic Medical College of Jiamusi University,Jiamusi 154007,China,2.The Third Affiliated Hospital of Jiamusi University,Jiamusi 154002,3.Microecology Research Center of Jiamusi University,China) |
| Abstract: | Objective To hypothesize that Radix codonopsis mixture could treat intestinal infection and endotoxemia of multiple organ dysfunction syndrome(MODS) by adjusting intestinal dysbacteriosis,repairing intestinal barrier function,and controlling bacteria and toxins translocation.Method MODS was induced by intestinal ischemia-reperfusion.These rats were treated with Radix codonopsis mixture and LiZhuChangLe(LZCL) respectively.Samples of intestinal contents,liver,spleen,mesenteric lymph nodes and portal vein were... |
| Keywords: | Radix codonopsis mixture Intestinal bacteria Bacteria translocation Multiple organ dysfunction syn-drome |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |