Real-time imaging of neural activity during binaural interaction in the guinea pig auditory cortex |
| |
Authors: | Y Hosokawa J Horikawa M Nasu I Taniguchi |
| |
Institution: | (1) Department of Neurophysiology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo, 101, Japan Fax: +81-3-5280-8073 e-mail: hosokawa.nphy@mri.tmd.ac.jp, JP |
| |
Abstract: | Spatio-temporal patterns of binaural interaction in the guinea pig auditory cortex (AC) were observed using optical recording
with a 12 × 12 photodiode array and a voltage-sensitive dye. The amplitudes of the sound-induced light signals from the cortex
were transformed into sequential two-dimensional images every 0.58 ms. Binaural sound stimuli evoked an excitatory response
followed by a strong inhibition, and contralateral stimuli evoked a strong excitatory response followed by a weak inhibition.
Ipsilateral sound stimuli evoked a weak response. Binaural stimulation induced two types of ipsilateral inhibition: a fast
binaural inhibition which was detected only after the contralateral and ipsilateral responses were subtracted from the binaural
responses, and which appeared 12–25 ms after the onset of stimulation, and a slow binaural inhibitory effect which was clearly
observed in the binaural responses themselves, appearing 70–95 ms after the onset of stimulation. The fast binaural inhibition
was observed in the same area as the contralateral excitatory response. The inhibited area became stronger and more widespread
with increasing intensity of ipsilateral stimulation. We did not observe the specialized organization of binaural neurons
as electrophysiologically found in the cat AC, in which binaural neurons of the same binaural response type are clustered
together and alternate with clusters of other response types.
Accepted: 14 August 1997 |
| |
Keywords: | Binaural responses Optical recording Guinea pig Auditory cortex |
本文献已被 SpringerLink 等数据库收录! |
|