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HDAC inhibitor DWP0016 suppresses miR-22 to induce growth inhibition and apoptosis via p53-independent PTEN activation in neuroblastoma SH-SY5Y cells
Authors:Hui Jin  Lifeng Liu  Weiping Deng  Yanhua Lu  Jianhui Tian  Hegeng Li  Jianwen Liu
Affiliation:1. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, National Clinical Research Centre for Traditional Chinese Medicine and Oncology, Shanghai 200032, China;3. School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Abstract:
Keywords:HDAC inhibitor  Apoptosis  miR-22  PTEN  PI3K/Akt pathway
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