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A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre |
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| Authors: | Deborah Merrick Tao Ting Lukas Kurt Josef Stadler Janet Smith |
| Affiliation: | (1) School of Biosciences, University of Birmingham Edgbaston, Birmingham, B15 2TT, UK;(2) School of Biomedical Sciences, Nottingham University Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK;(3) Geriatric department, Ruijin Hospital, Shanghai Second Medical University, 200025 Shanghai, People's Republic of China |
| Abstract: | BackgroundFibre type specification is a poorly understood process beginning in embryogenesis in which skeletal muscle myotubes switch myosin-type to establish fast, slow and mixed fibre muscle groups with distinct function. Growth factors are required to establish slow fibres; it is unknown how fast twitch fibres are specified. Igf-2 is an embryonically expressed growth factor with established in vitro roles in skeletal muscle. Its localisation and role in embryonic muscle differentiation had not been established. |
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