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The discovery of novel indole-2-carboxamides as cannabinoid CB(1) receptor antagonists |
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| Authors: | Cowley Phillip M Baker James Barn David R Buchanan Kirsteen I Carlyle Ian Clark John K Clarkson Thomas R Deehan Maureen Edwards Darren Goodwin Richard R Jaap David Kiyoi Yasuko Mort Chris Palin Ronald Prosser Alan Walker Glenn Ward Nick Wishart Grant Young Trevor |
| Institution: | Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@merck.com |
| Abstract: | The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB(1) antagonist. |
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