Epidemiological studies on aging in France: from the PAQUID study to the Three-City study |
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| Authors: | Alpérovitch Annick Amouyel Philippe Dartigues Jean-François Ducimetière Pierre Mazoyer Bernard Ritchie Karen Tzourio Christophe |
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| Affiliation: | 1. Inserm, unité 360, hôpital de la Salpêtrière, 75651 Paris cedex 13, France;2. Inserm, unité 508, institut Pasteur de Lille, BP 245, 59019 Lille cedex, France;3. Inserm, unité 330, université Victor-Segalen, Bordeaux-2, 33076 Bordeaux cedex, France;4. Inserm, unité 258, 94807 Villejuif cedex, France;5. URM 6095, CNRS–CEA, GIP Cyceron, BP 5229, 14074 Caen, France;6. Inserm EPI 99-30, hôpital La Colombière, BP 34493, 34093 Montpellier cedex, France |
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| Abstract: | Follow-up of cohorts recruited in general population with active screening and diagnosis of incident cases, is the most appropriate epidemiological design for studying incidence and risk factors of Alzheimer disease and other types of dementia. In France, people considered in the PAQUID study, then in the EVA study, have been the first cohorts on dementia. They have prepared the way for the Three-City (3C) study, conducted in Bordeaux, Dijon and Montpellier. About 9500 persons aged 65 years and over have been recruited in these three cities and will be followed-up during four years. The main objective of the 3C study is to investigate the relation between vascular risk and neurodegenerative diseases. The 3C study will provide essential data for defining strategies for dementia prevention. To measure the impact of the strategies on the incidence of dementia and the social burden of this disease will be an important public health objective in the near future. |
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| Keywords: | cohorts incidence study risk factors dementia Alzheimer disease cohortes incidence facteurs de risque démence maladie d’Alzheimer |
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