Energy potential of the cerebral cortex in the pre-agonal and post-resuscitation period after acute blood loss

In experiments on dogs it was revealed that during the preagonal period, after a four-hour hypovolemic hypotension, the content of ATP was reduced in the gray matter of the brain by 38 percent, and of ADP and AMP increased by 121 percent and 875 percent, respectively. Reflecting these shifts the energy charge potential decreased from 0.931 to 0.733 (P less than 0.05). At the early and remote postrescucitation period the content of metabolites and of energy charge potential failed to differ from the initial level.