3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes |
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Authors: | Hashimoto Takashi Sano Takashi Ito Wakana Kanazawa Kazuki Danno Gen-ichi Ashida Hitoshi |
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Institution: | Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, USA. |
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Abstract: | A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido4,3-b]indole (Trp-P-1) at 20 microM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 microM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases. |
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