Association between Exposure to Environmental Tobacco Smoke and Biomarkers of Oxidative Stress Among Patients Hospitalised with Acute Myocardial Infarction |
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Authors: | Ian L Megson Sally J Haw David E Newby Jill P Pell |
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Institution: | 1. Free Radical Research Facility, Department of Diabetes and Cardiovascular Science, University of Highlands and Islands, Inverness, United Kingdom.; 2. School of Nursing, Midwifery and Health, University of Stirling, Stirling, United Kingdom.; 3. Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.; 4. Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.; University of Rochester Medical Center, United States of America, |
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Abstract: | ObjectiveTo determine whether exposure to environmental tobacco smoke was associated with oxidative stress among patients hospitalised for acute myocardial infarction.DesignAn existing cohort study of 1,261 patients hospitalised for acute myocardial infarction.SettingNine acute hospitals in Scotland.ParticipantsSixty never smokers who had been exposed to environmental tobacco smoke (admission serum cotinine ≥3.0 ng/mL) were compared with 60 never smokers who had not (admission serum cotinine ≤0.1 ng/mL).InterventionNone.Main outcome measuresThree biomarkers of oxidative stress (protein carbonyl, malondialdehyde (MDA) and oxidised low-density lipoprotein (ox-LDL)) were measured on admission blood samples and adjusted for potential confounders.ResultsAfter adjusting for baseline differences in age, sex and socioeconomic status, exposure to environmental tobacco smoke was associated with serum concentrations of both protein carbonyl (beta coefficient 7.96, 95% CI 0.76, 15.17, p = 0.031) and MDA (beta coefficient 10.57, 95% CI 4.32, 16.81, p = 0.001) but not ox-LDL (beta coefficient 2.14, 95% CI −8.94, 13.21, p = 0.703).ConclusionsExposure to environmental tobacco smoke was associated with increased oxidative stress. Further studies are requires to explore the role of oxidative stress in the association between environmental tobacco smoke and myocardial infarction. |
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