A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype |
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| Authors: | Jung Y T Kozak C A |
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| Affiliation: | Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. |
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| Abstract: | ![]()
The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns. |
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