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On the role of NMDA receptors in blood pressure regulation in spontaneously hypertensive rats (SHR) |
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| Authors: | S. Glazewski M. Remiszewska M. Wutkiewicz Z. Jastrzebski W. Danysz |
| Affiliation: | (1) Department of Neurophysiology, Nencki Institute, Warsaw, Poland;(2) Department of Pharmacology, Institute of Drug Research and Control, Warsaw, Poland;(3) Department of Pharmacology, Merz + Co., P.O. Box 11 13 53, D-60048 Frankfurt / Main, Germany |
| Abstract: | Summary In the present study the binding of [3H]MK-801 to glutamatergic receptors of the NMDA type was compared in spontaneously hypertensive (SHR) and normotensive (WKY) rats in various brain structures (including nucleus tractus solitarii) by quantitative receptor autoradiography. Additionally, blood pressure changes after treatment with the NMDA antagonist MK-801 were studied in both strains. There were no differences between SHR and WKY rats either in the level of [3H]MK-801 binding or in the hypertensive reaction to MK-801. |
| Keywords: | Amino acids Autoradiography [3H]MK-801 SHR WKY rats Blood pressure Hypertension |
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