| 自由基、天然抗氧化剂与神经退行性疾病 |
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| 引用本文： | 赵保路.自由基、天然抗氧化剂与神经退行性疾病[J].生物物理学报,2010(4). |
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| 作者姓名： | 赵保路 |
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| 作者单位： | 中国科学院生物物理研究所;脑与认知国家重点实验室; |
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| 基金项目： | 国家自然科学基金项目(29935080); “973”项目(2006CB500700)~~ |
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| 摘 要： | 神经退行性疾病,老年痴呆症(Alzheimer's disease,AD)、帕金森症(Parkinson'sDisease,PD)和中风(脑卒中)严重危害老年人的身体健康和生活质量。这些疾病的发病机制目前尚不完全清楚,也无有效治疗方法。目前的研究发现,氧化应激产生的活性氧和NO自由基在诱导细胞的凋亡和导致神经退行性疾病AD、PD和中风方面发挥了重要作用。该文章综述了神经退行性疾病的自由基机理和天然抗氧化剂对这些疾病的预防和治疗作用机理。天然抗氧化剂,如茶多酚,能够防止6-羟多巴胺(6-hydroxydopamine,6-OHDA)诱导的细胞凋亡,保护线粒体功能从而预防6-OHDP诱导大鼠的PD症状;大豆异黄酮和尼古丁作为抗氧化剂可以防止Amyloid-β(Aβ)诱导的海马细胞凋亡和转基因小鼠脑中Aβ的沉积,抑制6-OHDA诱导细胞凋亡过程线粒体细胞色素C释放。在转基因鼠海马CA1区的Aβ斑中,铜、铁浓度比周围神经明显增高,用尼古丁处理明显减少海马CA1区Aβ斑及其周围神经中铜和铁的浓度,尼古丁可以抑制分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)的激活,核因子...
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| 关 键 词： | 活性氧自由基 天然抗氧化剂 线粒体 大豆异黄酮 氧化应激 尼古丁 清除自由基 茶多酚 神经退行性疾病 一氧化氮 |
Free Radicals, Natural Antioxidants and Neurodegenerative Disease |
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| ZHAO Baolu State Key Laboratory of Brain , Cognitive Science.Free Radicals, Natural Antioxidants and Neurodegenerative Disease[J].Acta Biophysica Sinica,2010(4). |
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| Authors: | ZHAO Baolu State Key Laboratory of Brain Cognitive Science |
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| Institution: | ZHAO Baolu State Key Laboratory of Brain , Cognitive Science,Institute of Biophysics,Chinese Academy of Science,Beijing 100101,China |
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| Abstract: | The neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease (PD) and stroke seriously affect the health and life quality, which are becoming a social problem. The pathogenesis of these diseases is not clear and there is no effective method to cure them. The free radical mechanism for neurodegenerative diseases, prevention and curative mechanisms of natural antioxidants against these diseases are reviewed in this paper. Reactive oxygen species (ROS) and NO free radicals generated from oxida... |
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| Keywords: | Free radicals Natural antioxidants Neurodegenerative diseases Parkinson\'s disease Alzheimer\'s disease Stroke |
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