The reducing activity of S-aminoethylcysteine ketimine and similar sulfur-containing ketimines. |
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Authors: | S P Solinas L Pecci G Montefoschi D Cavallini |
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Affiliation: | Dipartimento di Scienze Biochimiche, A. Rossi Fanelli, Università di Roma La Sapienza, Italy. |
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Abstract: | S-aminoethylcysteine ketimine and other sulfur-containing similar ketimines reduce molecular oxygen and phospho-18-tungstate (Folin Marenzi reagent), although the sulfur atom is formally present in the non reducing thioether form. We have now found that 2,6-diclorophenolindophenol, some ferrihemoproteins and other reagents are also reduced by this group of ketimines. Ferricytochrome c is reduced faster than methemoglobin, metmyoglobin and free hematin, whereas horse radish peroxidase compound I is reduced at once. These results indicate a wider reducing activity of this type of ketimine. The oxidation of ketimines by ferric cytochrome c appears a relevant finding pointing to a new possible way of enzymatic modification of sulfur-ketimines in tissues. |
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