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Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4 |
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| Authors: | Sujata Sarkar Laura A Cooney Peter White Deborah B Dunlop Judith Endres Julie M Jorns Matthew J Wasco David A Fox |
| Institution: | (1) Section of Rheumatology, Department of Medicine, University of Arizona, 1501 N. Campbell Avenue, Rm 6310, Tucson, Arizona 85724, USA;(2) Division of Rheumatology, Department of Internal Medicine, and Rheumatic Disease Core Center, University of Michigan, 1500 E Medical Center Drive, 3918 Taubman Center, SPC 5358, Ann Arbor, Michigan 48109, USA;(3) Department of Pathology, University of Michigan, 1301 Catherine, 5240 Medical Science 1, Ann Arbor, Michigan 48109, USA |
| Abstract: | IntroductionInterleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-γ and IL-4 have been shown to suppress Th17 development in vitro, but their potential immunoregulatory roles in vivo are uncertain. The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-γ and IL-4. |
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