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Evolution of the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus in Morocco During Two Influenza Seasons 2009–2011 |
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| Authors: | Hicham El Rhaffouli El Mostafa El Fahime Abdellilah Laraqui Tahar Bajjou Marouane Melloul Susan Obeid Lahoussine Fathallah Idriss Lahlou-Amine |
| Institution: | 1. Biosafety Level 3 and Research Laboratory (LRB-P3), Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, University Mohammed V-Souissi, Hay Ryade, BP 190, Rabat, Morocco 2. Technical Units Supporting Scientific Research, National Center for Scientific and Technical Research, Rabat, Morocco 3. Rega Institute for Medical Research, KU Leuven, Louvain, Belgium 4. Royale Armed Forces, Military Health Service, Rabat, Morocco |
| Abstract: | To study genetic evolution of Moroccan influenza A(H1N1)pdm09 virus strains, we conducted a molecular characterization of the hemagglutinin gene subunit 1 (HA1) of 36 influenza A(H1N1)pdm09 virus strains. The stains were collected from patients in Rabat and Casablanca during two influenza seasons 2009–2010 and 2010–2011. Nucleotide and amino acid sequences of 14 influenza A(H1N1)pdm09 virus strains from 2009 to 2010 were ~97 and 99 %, respectively, similar to the reference strain A/California/07/2009 (H1N1). Phylogenetic analysis of 22 influenza A(H1N1)pdm09 virus strains from 2010 to 2011 revealed a co-circulation of three well-described different genetic groups. Most important, none of the identified groups showed significant changes at the antigenic site of the virus HA1 subunit which may alter the efficacy of California/07/2009 (H1N1) vaccine. |
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