Cooperative omega loops in cytochrome c: role in folding and function |
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| Authors: | Krishna Mallela M G Lin Yan Rumbley Jon N Englander S Walter |
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| Affiliation: | Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, 422 Curie Blvd, 1007 Stellar Chance Bldg, Philadelphia, PA 19104-6059, USA. mmg@hx2.med.upenn.edu |
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| Abstract: | Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties. |
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| Keywords: | omega loop protein folding hydrogen exchange cytochrome c protein function |
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