Composition of splenic T lymphocytes in allophenic mice. |
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| Authors: | J L McIvor L E Bolcsak C M Warner |
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| Affiliation: | 1. Center for Blood Research, Peter B. Brigham and Robert B. Brigham Hospitals, Boston, Massachusetts 02115 U.S.A.;2. Departments of Biological Chemistry and Medicine, Harvard Medical School, Boston, Massachusetts 02115 U.S.A. |
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| Abstract: | Guinea pig peritoneal macrophages were activated in vitro by culturing with MAF (macrophage activating factor)-containing fractions from stimulated lymphocytes. These macrophage preparations demonstrate a 60% increase in the production of prostaglandins of the E series (PGE) when compared with macrophages cultured with fractions from unstimulated lymphocytes. PGE accumulation in macrophage cultures is maximal after 24 hr with MAF; tumor cytotoxicity is also maximal at this time. The final PGE concentration in cultures of activated macrophages averaged 3 × 10?8M. |
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| Keywords: | To whom requests for reprints should be addressed. |
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