兴奋下丘脑弓状核神经元降低大鼠血浆唾液酸水平的作用

实验采用下丘脑弓状核（ＡＲＣ）区微量注射和紫外分光光度测定法，研究ＡＲＣ区注射不同浓度谷氨酸钠（Ｇｌｕ）对大鼠血浆唾液酸（ＳＡ）水平的影响。结果表明：（１）ＡＲＣ区注射Ｇｌｕ后，血浆ＳＡ水平较对照组明显降低（Ｐ〈０．０１），而且随Ｇｌｕ浓度的增加，血浆ＳＡ水平降低所需的时间逐渐缩短；（２）侧脑室注射阿朴吗啡后，ＡＲＣ区注射Ｇｌｕ，血浆ＳＡ水平明显降低（Ｐ〈０．０１），而且降低发生时间较对照组提前：

EXCITATION OF HYPOTHALAMIC NUCLEUS ARCUATUS NEURON INDUCED DECREASE OF PLASMASIALIC ACID LEVEL IN RATS

The effect of sodium glutamate (Gln) on plasma static acid (SA) level was studied by means of microinjection into the nucleus arcuatus (ARC) and ultroviolet spectrophotometry.The results indicate: (1 ) The plasma SA level was significantly decreased after microinjection of Gin into the ARC (P<0. 01 ). With increasing Glu concentration,the onset of the decrease occurred earlier. (2) When Glu was microinjected into ARC after intraventricular injection of apomorphine, the plasma SA level was significantly decreased (P<0. 01 ) and the time required to cause the decrease was shortened.(3)When Gin was microinjected into ARC after intraventricular injection of spiperone,no change was found in the plasma SA level (P>0. 05). The above results suggest that the mechanism underlying the decrease of plasma SA level is probably related to modulated dopamine (DA) release of hypothalamic dopaminergic neurons by DA-D2 recedetor.