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Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome,a preliminary report
Authors:Mohammad Hashemi  Hamzeh Rezaei  Ebrahim Eskandari-Nasab  Mahmoud Ali kaykhaei  Zahra Zakeri  Mohsen Taheri
Affiliation:1. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;3. Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;4. Genetic of Non Communicable Disease Research Center, Zahedan University of Medical Science, Zahedan, Iran
Abstract:
Metabolic syndrome (MeS) is associated with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. There is some evidence indicating that adipokines play a role in the development of MeS. The present study was aimed to investigate the impact of chemerin rs17173608 and vaspin rs2236242 gene polymorphisms with the risk of MeS in a sample of Iranian population.
Keywords:ACE, Angiotensin-1-converting enzyme   AHA/NHLBI, American Heart Association/National Heart, Lung and Blood Institute   BMI, body mass index   CIDEA, cell death-inducing DNA fragmentation factor alpha-like effector A   CMKLR1, chemokine-like receptor 1   CI, confidence intervals   eNOS, endothelial nitric oxide synthase   HOMA-IR, homeostasis model assessment estimated-insulin resistance   IDF, international diabetes federation   MeS, metabolic syndrome   NCBI, National Center for Biotechnology Information   NCEP-ATP III, national cholesterol education program-adult treatment panel III   OR, odds ratio   PON, paraoxonase   PCR, polymerase chain reaction   T2DM, type 2 diabetes mellitus   VAT, visceral adipose tissue   WHR, waist to hip ratio
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