Do microRNAs regulate bone marrow stem cell niche physiology? |
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Authors: | SK Laine T HentunenT Laitala-Leinonen |
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Institution: | Skeletal Biology Consortium, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland |
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Abstract: | The adult bone marrow, situated within the bone cavity, comprises three distinct stem cell populations: hematopoietic stem cells (HSCs), mesenchymal stromal/stem cells (MSCs) and endothelial progenitor/stem cells (EPCs). HSCs are a well-characterized population of self-renewing cells that give rise to all blood cells. The definition of MSCs is more complex due to the limited understanding of MSC properties. In general, MSCs are considered multipotent stromal cells that are able to differentiate into various cell types, including osteoblasts, chondrocytes and adipocytes. Compared to HSCs and MSCs, EPCs are a newly discovered population of stem/progenitor cells with the capacity to differentiate into endothelial cells, the cells forming the inner lining of a blood vessel. |
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Keywords: | miRNA microRNA HSC hematopoietic stem cell MSC mesenchymal stem cell EPC endothelial progenitor cell UTR untranslated region |
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