Antitumor activity of Nocardia cell wall skeleton preparations in transplantable tumors in syngeneic mice and patients with malignant pleurisy |
| |
| Authors: | Ichiro Azuma Mikio Yamawaki Kosei Yasumoto Yuichi Yamamura |
| |
| Institution: | (1) The Third Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, 553 Osaka, Japan;(2) Department of Chest Surgery, Kyushu Cancer Center Hospital, Minami-ku, 815 Fukuoka, Japan |
| |
| Abstract: | Summary The antitumor activity of the cell wall skeleton preparations of four species of Nocardia, N. brasiliensis strain 146, N. coeliaca strain 122, N. polychromogenes strain 6, and N. rubra, which showed potent adjuvant activity on the induction of cell-mediated cytotoxicity in allogeneic mice, was examined with the aid of EL-4 leukemia, melanoma B16, and MH-134 hepatoma in syngeneic mice. Preliminary clinical trials were performed and the results suggest that the cell wall skeleton of N. rubra, upon intrapleural injection, may be useful as an immunotherapeutic agent for patients with malignant pleurisy. The chemical properties of these cell wall skeleton preparations are described. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
