Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form |
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Authors: | Kurz Tino Brunk Ulf T |
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Institution: | Division of Pharmacology, Faculty of Health Sciences, Link?ping University, Link?ping, Sweden. |
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Abstract: | Lysosomes contain most of the cell's supply of labile iron, which makes them sensitive to oxidative stress. To keep lysosomal labile iron at a minimum, a cellular strategy might be to autophagocytose iron binding proteins that temporarily would chelate iron in a non-redox-active form. Previously we have shown that autophagy of metallothioneins, as well as of non-Fe-saturated ferritin, meets this goal. Here we add another stress-regulated protein to the list, namely HSP70. |
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