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The lantibiotic mersacidin is a strong inducer of the cell wall stress response of <Emphasis Type="Italic">Staphylococcus aureus</Emphasis>
Authors:Peter Sass  Andrea Jansen  Christiane Szekat  Vera Sass  Hans-Georg Sahl  Gabriele Bierbaum
Institution:(1) Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
Abstract:

Background  

The lantibiotic mersacidin is an antimicrobial peptide of 20 amino acids that is ribosomally produced by Bacillus sp. strain HIL Y-85,54728. Mersacidin acts by complexing the sugar phosphate head group of the peptidoglycan precursor lipid II, thereby inhibiting the transglycosylation reaction of peptidoglycan biosynthesis.
Keywords:
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