Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L. |
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| Authors: | Jun-Li Han Ben-Ye Liu He-Chun Ye Hong Wang Zhen-Qiu Li Guo-Feng Li |
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| Affiliation: | Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China;;Graduate University of the Chinese Academy of Sciences, Beijing 100039, China;;College of Life Sciences, Hebei University, Baoding, Hebei 071002, China |
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| Abstract: | Artemisinin Is a novel effective antimalarial drug extracted from the medicinal plant Artemisia annua L. Owing to the tight market and low yield of artemislnin, there is great interest in enhancing the production of artemisinin.In the present study, farnesyl dlphosphate synthase (FPS) was overexpressed in high-yield A. annua to increase the artemislnin content. The FPS activity in transgenic A. annua was two- to threefold greater than that in non-transgenic A. annua. The highest artemisinin content in transgenic A. annua was approximately 0.9% (dry weight), which was 34.4% higher than that in non-transgenic A. annua. The results demonstrate the regulatory role of FPS in artemisinin biosynthesis. |
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| Keywords: | Artemisia annua artemisinin artemisinin content farnesyl diphosphate synthase overexpression |
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