首页 | 本学科首页   官方微博 | 高级检索  
     


On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior
Authors:T. B. Kalinnikova  R. R. Kolsanova  R. R. Shagidullin  E. B. Osipova  M. Kh. Gaynutdinov
Affiliation:19790. Institute for Problems of Ecology and Mineral Wealth Use, Tatarstan Academy of Sciences, Kazan, 420087, Russia
Abstract:
Serotonin reduces the behavior tolerance of Caenorhabditis elegans of the N2 wild-type strain (swimming induced by the mechanical stimulus) to a temperature of 36°C. The sensitivity to the serotonin influence on the behavior thermotolerance remains intact in strains with null mutations of mod-1(ok103) and ser-1(ok345) serotonin receptor genes, and is almost completely lost in the ser-4(ok512) strain with null mutation in the gene of the SER-4 serotonin receptor, which is a homologue of 5-HT1 mammalian serotonin receptor. In addition, nematodes of the ser-4(ok512) strain have high behavior thermotolerance in the absence of the exogenous serotonin compared to the N2 strain. These data indicate the involvement of the ser-4 gene in the serotonin regulation of the tolerance of C. elegance nervous system functions to hyperthermia.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号