Further halotyrosine derivatives from the marine sponge Suberea aff. praetensa |
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| Authors: | Kijjoa Anake Watanadilok Rawiwan Sonchaeng Pichai Sawangwong Pichan Pedro Madalena Nascimento Maria São José Silva Artur M S Eaton Graham Herz Werner |
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| Institution: | Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal. |
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| Abstract: | Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5-chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines. |
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