Evolutionary History of MHC Class I Genes in the Mammalian Order Perissodactyla |
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Authors: | EC Holmes SA Ellis |
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Institution: | (1) The Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK, GB;(2) Institute for Animal Health, Compton, Nr Newbury, RG20 7NN, UK, GB |
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Abstract: | We carried out an analysis of partial sequences from expressed major histocompatibility complex (MHC) class I genes isolated
from a range of equid species and more distantly related members of the mammalian order Perissodactyla. Phylogenetic analysis
revealed a minimum of six groups, five of which contained genes and alleles that are found in equid species and one group
specific to the rhinoceros. Four of the groups contained only one, or very few sequences, indicating the presence of relatively
nonpolymorphic loci, while another group contained the majority of the equid sequences identified. These data suggest that
a diversification of MHC genes took place after the split between the Equidae and the Rhinocerotidae yet before the speciation
events within the genus Equus.
Received: 17 November 1998 / Accepted: 7 April 1999 |
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Keywords: | : Major histocompatibility complex — Perissodactyls — Rhinoceros — Phylogeny — Polymorphism |
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