中药抗心肌缺血再灌注损伤的信号通路研究进展

冠心病发生率、致死率高，严重危害人类健康。心肌缺血再灌注损伤是加重心肌损伤的主要病理机制，干预再灌注损伤挽救激酶、 单磷酸腺苷激酶、蛋白激酶 C 等信号传导通路保护心肌，成为减轻心肌损伤的重要途径之一。综述近 3 年国际期刊收录的中药有效成分、 提取物及复方制剂调节相关信号传导通路， 减轻心肌再灌注损伤的研究进展， 以期为阐释中药的作用特点， 有效防治心血管疾病提供参考。

A dvances in Researches on Signal Transduction Pathways Involved in the Protection against Myocardial Ischemia Reperfusion Injury by Traditional Chinese Medicines

With high incidence and mortality rate, coronary heart disease (CHD) poses great threat to human health. Myocardial ischemia/ reperfusion injury is the major pathological mechanism that aggregates myocardial damage. Intervention in signaling pathways of reperfusion injury salvage kinase (RISK), adenosine 5'' -monophosphate (AMP)-activated protein kinase and protein kinase C, etc plays an important role in attenuation of myocardial reperfusion injury. Many traditional Chinese medicines (TCMs) can protect against myocardial ischemia reperfusion (I/R) injury. The present review highlights the advance in researches(published in international journals in recent 3 years) on signaling transduction pathways regulated by TCM (including effective components, extracts and compound preparations) in the protection against myocardial I/R injury, so as to provide references for elucidation of acting mechanisms of TCM and effective prevention of cardiovascular diseases.