Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii |
| |
Authors: | Feng Jiaquan Zhang Rujun Zhou Yu Chen Zhenhua Tang Wei Liu Qunfang Zuo Jian-Ping Zhao Weimin |
| |
Institution: | Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. |
| |
Abstract: | Nine pregnane glycosides containing peroxy functions in their sugar moieties (1-5 and 11-14), five oligosaccharides (6-10), six pregnane glycosides (15-20), and five cardiac glycosides (21-25) were isolated from the root barks of Periploca sepium Bge. (Asclepiadaceae) and the roots of Periploca forrestii Schltr. (Asclepiadaceae), two traditional Chinese medicines used for the treatment of rheumatoid arthritis. Among them, 1-8 are hitherto unknown. Their structures were characterized on the basis of spectroscopic analyses. In pharmacological testing, compounds 1-5 and 11-14 were found to exhibit inhibitory activity against the proliferation of T lymphocyte in vitro with IC50 values ranging from 0.29microM to 1.97microM, while the other components showed no significant inhibitory activity. |
| |
Keywords: | Periploca sepium Periploca forrestii Asclepiadaceae Immunosuppressive Pregnane glycoside |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|