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Quantitative mass spectrometry reveals the epigenome as a target of arsenic
Authors:Chu Feixia  Ren Xuefeng  Chasse Amanda  Hickman Taylor  Zhang Luoping  Yuh Jessica  Smith Martyn T  Burlingame Alma L
Affiliation:Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Abstract:
Recent studies reveal that posttranslational modifications on chromatin proteins, especially histones, organize genomic DNA and mediate various cellular responses to environmental influences. Quantitative mass spectrometric analysis is a powerful approach to reveal these dynamic events on chromatin in a systematic manner. Here, the effects of arsenic exposure on histone epigenetic state were investigated in human UROtsa cells, and a reduction in acetylation level on several histone H3 and H4 lysine residues was detected. Furthermore, MYST1 was shown to be the major histone acetyltransferase for H4 Lys16 and protect UROtsa cells from arsenic toxicity.
Keywords:
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