Altered antigenicity is seen in the lipopolysaccharide profile of non-serotypeable Actinobacillus actinomycetemcomitans strains |
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Authors: | Paju S Saarela M Chen C Jousimies-Somer H Uitto V Asikainen S |
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Institution: | Institute of Dentistry, P.O. Box 41, University of Helsinki, FIN-00014, Helsinki, Finland. susanna.paju@helsinki.fi |
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Abstract: | Non-serotypeable Actinobacillus actinomycetemcomitans strains may be derived from the serotypeable ones. In the present study, we compared the outer membrane proteins (OMPs) and lipopolysaccharides (LPSs) of serotypeable and non-serotypeable A. actinomycetemcomitans strains (n=24) of the same genotype in the same subject (n=6) to find out if alterations on the cell-surface contribute to the non-serotypeability. Serotypeable and non-serotypeable A. actinomycetemcomitans strains showed great similarity in the OMP patterns both within and between subjects. Using serotype-specific antisera, clear immunoblotting LPS profiles in the O-antigenic region were seen in serotype b and c strains but not in non-serotypeable strains from the same subjects. The results suggest that changes in LPS lead to the altered antigenicity of non-serotypeable A. actinomycetemcomitans strains. |
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Keywords: | Serotype Non-serotypeability Lipopolysaccharide Periodontal disease Actinobacillus actinomycetemcomitans |
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