| 重组人巨噬细胞集落刺激因子的结构与功能 |
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| 引用本文： | 凌明圣,徐明波,马贤凯.重组人巨噬细胞集落刺激因子的结构与功能[J].生物化学与生物物理进展,1994,21(4):326-330. |
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| 作者姓名： | 凌明圣 徐明波 马贤凯 |
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| 作者单位： | 北京军事医学科学院基础医学研究所;北京军事医学科学院基础医学研究所;北京军事医学科学院基础医学研究所 |
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| 摘 要： | 重组人粒细胞──巨噬细胞集落刺激因子(rhGM-CSF) 已经在原核、真核细胞表达并得到纯品，为它的结构与功能研究提供了有利条件．目前国内外对于rhGM-CSF的结构与功能研究主要集中在晶体结构、化学修饰、溶液中构象和稳定性以及突变和分子设计方面．分子结构与功能的关系以及与GM-CSF受体作用机理研究也取得了突破性进展．
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| 关 键 词： | 重组人粒细胞──巨噬细胞集落刺激因子 结构与功能 晶体结构 化学修饰 溶液 构象 |
| 收稿时间： | 5/5/1993 12:00:00 AM |
| 修稿时间： | 1993/8/12 0:00:00 |
Structure and Function of Recombinant Human Granulocyte-macrophage Colony-Stimulating Factor |
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| Ling Mingsheng,Xu Mingbo and Ma Xiankai.Structure and Function of Recombinant Human Granulocyte-macrophage Colony-Stimulating Factor[J].Progress In Biochemistry and Biophysics,1994,21(4):326-330. |
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| Authors: | Ling Mingsheng Xu Mingbo and Ma Xiankai |
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| Institution: | Institute of Basic Medical Sciences, Academy of Military Medical Sciences;Institute of Basic Medical Sciences, Academy of Military Medical Sciences;Institute of Basic Medical Sciences, Academy of Military Medical Sciences |
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| Abstract: | Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has been expressed in prokaryotic and eukaryotic cells. Purified to homogeneity, which facilitates to study the structure and function of this factor. Recently, the study of structure and function of rhGM-CSF has been mainly focused on crystal structure, including chemical modification. conformation and stability in solution, mutation and molecular design. The progress in study the structure-function relationship and the mechanism of interaction of GM-CSF with its receptor is discussed. |
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| Keywords: | rhGM-CSF structure and function crystal structure chemical modification conformation and stability in solution |
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