| 内皮抑素及其在抗肿瘤中的应用 |
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| 引用本文： | 赵媛媛,吕茂民,章金刚. 内皮抑素及其在抗肿瘤中的应用[J]. 生物技术通讯, 2009, 20(4): 572-575. DOI: 10.3969/j.issn.1009-0002.2009.04.035 |
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| 作者姓名： | 赵媛媛 吕茂民 章金刚 |
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| 作者单位： | 1. 军事医学科学院野战输血研究所,北京100850;解放军后勤指挥学院,北京100858
2. 军事医学科学院野战输血研究所,北京,100850 |
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| 摘 要： | 内皮抑素是一种抗血管生成的抑制因子，它特异性地作用于新生微血管的内皮细胞，其水平与肿瘤血管生成有着明显的相关性。体内外的研究均表明，内皮抑素具有无毒副作用、不容易产生耐药性和易达到有效药物浓度等优点。我们简要综述了内皮抑素的特性、作用机制，及其在抗肿瘤应用等方面的研究进展。
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| 关 键 词： | 内皮抑素 血管生成 肿瘤 |
Advance in Research of Endostatin and its Antitumor Application |
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| ZHAO Yuan-Yuan,LU Mao-Min,ZHANG Jin-Gang. Advance in Research of Endostatin and its Antitumor Application[J]. Letters in Biotechnology, 2009, 20(4): 572-575. DOI: 10.3969/j.issn.1009-0002.2009.04.035 |
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| Authors: | ZHAO Yuan-Yuan LU Mao-Min ZHANG Jin-Gang |
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| Affiliation: | 1. Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850; 2. Logistics Command College of PEA, Beijing 100858; China) |
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| Abstract: | Endostatin is a kind of angiogenesis inhibitor, specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation. In vivo and in vitro studies indicated that endostatin has some advantages such as least toxic and without side effects, hard to become drug resistant and easy to achieve an effective drug concentration. In this review we summarized the characteristics of endostatin, its mechanism and applied to antitumor. |
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| Keywords: | endostatin angiogenesis tumor |
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