Isoxazole-containing neonicotinoids: Design,synthesis, and insecticidal evaluation |
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| Authors: | Chao Lei Li Geng Xiaoyong Xu Xusheng Shao Zhong Li |
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| Institution: | 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, China |
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| Abstract: | A series of novel isoxazole-containing neonicotinoids were synthesized from nitromethylene analogues and aromatic aldehydes in the presence of l-proline/K2CO3. Bioassays indicated that several synthesized compounds showed 40–70% mortality against brown planthopper (Nilaparvata lugens) under the concentration of 4 mg L?1, higher than that of imidacloprid (20%). Against cowpea aphid (Aphis craccivora), the best activity of title compounds reached 90% at the concentration of 20 mg L?1. |
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| Keywords: | Isoxazole Neonicotinoids Synthesis Insecticidal activity Imidacloprid |
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