Quantitative trait loci affecting growth in high growth (hg) mice |
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Authors: | Pablo M Corva Simon Horvat Juan F Medrano |
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Institution: | (1) Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, California 95616-8521, USA, US;(2) Zootechnical Department, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia, SI |
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Abstract: | A genome-wide scan was performed in order to identify Quantitative Trait Loci (QTL) associated with growth in a population
segregating high growth (hg), a partially recessive mutation that enhances growth rate and body size in the mouse. A sample of 262 hg/hg mice was selected from a C57BL/6J-hg/hg× CAST/EiJ F2 cross and typed with 79 SSLP markers distributed across the genome. Eight significant loci were identified through interval
mapping. Loci on Chromosomes (Chrs) 2 and 8 affected the growth rate of F2 mice. Loci on Chr 2 and 11 affected growth rate and carcass lean mass (protein and ash). A locus on Chr 9 modified femur
length and another one in Chr 17 affected both carcass lean mass and femur length, but none of these had significant effects
on growth rate. Loci on Chrs 5 and 9 modified carcass fat content. Additive effects were positive for C57BL/6J alleles, except
for the two loci affecting carcass fatness. Typing of selected markers in 274 +/+ F2 mice revealed significant interactions between hg and other growth QTL, which were detected as changes in gene action (additive or dominant) and in allele substitution effects.
Knowledge about interactions between loci, especially when major genes are involved, will help in the identification of positional
candidate genes and in the understanding of the complex genetic regulation of growth rate and body size in mammals.
Received: 29 June 2000 / Accepted: 22 November 2000 |
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