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Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes.
Authors:R R Joshi  K N Ganesh
Affiliation:Biorganic Chemistry Unit, National Chemical Laboratory, Poona, India.
Abstract:It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction.
Keywords:
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