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Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes. |
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| Authors: | R R Joshi K N Ganesh |
| Affiliation: | Biorganic Chemistry Unit, National Chemical Laboratory, Poona, India. |
| Abstract: | It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction. |
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