Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes. |
| |
Authors: | R R Joshi K N Ganesh |
| |
Affiliation: | Biorganic Chemistry Unit, National Chemical Laboratory, Poona, India. |
| |
Abstract: | It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction. |
| |
Keywords: | |
|
|