Quantification of doxorubicin and validation of reversal effect of tea polyphenols on multidrug resistance in human carcinoma cells |
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| Authors: | Wei Dongzhi Mei Yuying Liu Jianwen |
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| Affiliation: | (1) State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, 200237, P.R. China |
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| Abstract: | ![]()
HPLC was used to analyze doxorubicin in multidrug-resistance (MDR) human carcinoma cells. This method is novel, simple, sensitive, linear, accurate and precise. The minimal detectable concentration is 0.2  g ml–1. The reversal effects of tea polyphenols on MDR are elucidated by this method. The results indicate that the tea polyphenol, (–)-epigallocatechin gallate, is a potential modulator of MDR. |
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| Keywords: | doxorubicin (– )-epigallocatechin gallate multidrug resistance tea polyphenols |
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