Searching for Molecular Players Differentially Involved in Neurotransmitter and Neuropeptide Release |
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| Authors: | Tao Xu Pingyong Xu |
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| Affiliation: | (1) National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P.R. China;(2) College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China |
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| Abstract: | Neurotransmitters and neuropeptides are stored in small clear vesicles (SCVs) and large dense core vesicles (LDCVs), respectively. Many differences in the properties of SCVs and LDCVs suggest that these two classes of secretory organelles may employ different sets of molecules in exocytosis. Relatively little is known, however, about factors that differentially participate in SCVs and LDCVs release. This article briefly overviews some key molecules that are possibly involved in the differential regulation of the trafficking, docking, priming and fusion of SCVs and LDCVs. Special issue article in honor of Dr. Ji-Sheng Han. |
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| Keywords: | Neurotransmitter Neuropeptide Small clear vesicle Large dense core vesicle Exocytosis |
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