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The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists |
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| Authors: | Lunniss Gillian E Barnes Ashley A Barton Nick Biagetti Matteo Bianchi Federica Blowers Stephen M Caberlotto Laura L Emmons Amanda Holmes Ian P Montanari Dino Norris Roz Puckey Gemma V Walters Dewi J Watson Steve P Willis John |
| Institution: | GlaxoSmithKline, Neurosciences Centre of Excellence for Drug Discovery, New Frontiers Science Park, Harlow, UK. gill@lunniss.net |
| Abstract: | The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure. |
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