新疆维吾尔族和汉族妇女宫颈脱落细胞中HPV Ll 壳蛋白的表达比较

目的:研究HPV L1壳蛋白在在新疆维吾尔族和汉族妇女宫颈脱落细胞中的表达情况及差异性。方法:收集2012年9月至2014年3月在新疆维吾尔自治区人民医院妇科门诊就诊或行宫颈癌机会性筛查的新疆维吾尔族和汉族妇女病例1160例,选择其中HPV感染阳性或TCT阳性或两项同时阳性的465例纳入研究队列,通过免疫细胞化学法检测宫颈脱落细胞中HPV L1蛋白的表达情况。结果:新疆维吾尔族与汉族妇女HPV L1壳蛋白的总阳性表达率比较无显著差异(P=0.964);维吾尔族与汉族妇女正常或慢性炎症组、CIN1组、CIN2组、CIN3组和SCC组HPV L1壳蛋白表达的阳性率比较均无显著差异(P=0.988,0.957,0.803,0.892,1.000)。新疆维吾尔族妇女和汉族妇女HPV L1壳蛋白表达的阳性率在C1N1组为最高,高于正常或慢性炎症组及其它高病变组,且HPV L1壳蛋白表达的阳性率随宫颈病变恶性程度的增加而降低,呈负相关(相关系数=-0.687和-0.379,P0.001)。结论:新疆维吾尔族与汉族妇女宫颈脱落细胞中HPV L1壳蛋白的表达不存在民族差异,但其与宫颈病变的恶性程度呈负相关,可能是宫颈病变的保护性因素之一。

Comparison of the Expression of HPV L1 Capsid Protein in the Cervical Exfoliated Cell between Uygur and Han Women in Xinjiang

Objective:To compare the expression of HPV L1 capsid protein in the cervical exfoliated cell between Uygur and Han women in Xinjiang.Methods:FromSeptember 2012 to March 2014, 1160 cases that consulted a doctor or had an opportunistic screening of cervical cancer were collected in the department of Xinjiang Uygur Autonomous Region People''s Hospital. All the cases were examined with ThinPrep Cytology Test (TCT) and HPV genotyping, and 465 cases with HPV infection positive or TCT positive or the both positive were included in the study cohort. All the cases included in the study cohort underwent colposcopy and biopsy, and the expression of HPV L1 capsid protein was detected by immunocytochemical method.Results:The total positive rate of HPV L1 capsid protein had no significant difference between Uygur and Han women (P=0.964), and the positive rate in normal or chronic inflammation group, and the positive rate of CIN1 group, CIN2 group, CIN3 group and SCC group also had no significant difference between Uygur and Han women(P=0.988, 0.957, 0.803, 0.892, 1.000), the positive rate of HPV L1 capsid protein was highest in CIN1 group, higher than normal or chronic inflammatory group and other high CIN group; the positive rate of HPV L1 capsid protein decreased with increase of malignancy (r = -0.687 and -0.379, P<0.001).Conclusion:The expression of HPV L1 capsid protein had no significant difference between Uygur and Han women in Xinjiang, and HPV Ll capsid protein was negatively correlated with the malignancy of cervical lesions for Uygur and Han women in Xinjiang.