| Wnt5a及其信号通路与血管新生的研究进展 |
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| 引用本文： | 倪亚光,石雅宁,朱能,敖宝学,曾嵘,廖端芳,覃丽.Wnt5a及其信号通路与血管新生的研究进展[J].现代生物医学进展,2016,16(11):2191-2196. |
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| 作者姓名： | 倪亚光 石雅宁 朱能 敖宝学 曾嵘 廖端芳 覃丽 |
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| 作者单位： | 南华大学药物药理研究所；湖南中医药大学药学院；湖南中医药大学第一附属医院 |
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| 基金项目： | 国家自然科学基金项目（81000946，81270359，81173047，31371161）；湖南省教育厅重点项目(15A138，12A107)；
中药学湖南省重点学科科技项目（zy201502）；湖南省科技厅项目（2014FJ3086） |
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| 摘 要： | Wnt5a是Wnt蛋白家族中的成员之一,在细胞成熟、胚胎发育等过程中发挥着重要作用。研究表明Wnt5a的表达调控及其信号通路与血管新生密切相关,并且在血管新生性相关疾病中发挥了重要作用。本文从Wnt5a与其相关信号转导通路对血管新生的影响以及分子机制等方面进行阐述和展望,旨在为以Wnt5a为靶点进行血管新生性疾病的防治提供理论依据。
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| 关 键 词： | Wnt5a 血管新生 信号通路 |
Research Progress of Wnt5a and Its Signaling Pathway in Angiogenesis |
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| Abstract: | Wnt5a is a member of the Wnts protein family, which plays an important role in the process of cell maturation, embryonic
development and so on. It has been shown that the expression of Wnt5a and its signaling pathway are closely related to angiogenesis,
which play an important role in angiogenesis related diseases. In this literature review, we summarized data on wnt5a and its signaling
pathway and their involvement in angiogenesis and related diseases. Further comprehensive understanding of the function and relationship
between wnt5a and angiogenesis would enable us to develop novel diagnostic and therapeutic targets for prevention and treatment of
vascular diseases. |
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| Keywords: | Wnt5a Angiogenesis Signaling pathway |
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