131I对男性甲状腺功能亢进症血清性激素及甲状腺球蛋白水平影响研究

目的:探讨~(131)I对男性甲状腺功能亢进症患者血清性激素及甲状腺球蛋白水平的影响。方法:收集我院收治的男性甲状腺功能亢进症患者74例,随机分为对照组和实验组,每组各37例,对照组患者给予他巴唑口服,20-30 mg/次,每日口服1次。实验组患者在对照组基础上给予~(131)I治疗。治疗结束后,检测并比较两组患者血清游离三碘甲状腺素(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、睾酮(T)、雌二醇(E2)、甲状腺球蛋白(TG)水平的变化以及临床疗效。结果:与治疗前相比,两组患者血清FT3、FT4、T、E2、TG水平均显著下降,TSH水平明显升高(P0.05);与对照组相比,实验组患者血清FT3、FT4、T、E2、TG水平较低,TSH水平以及临床治疗有效率较高(P0.05)。结论:~(131)I能够显著降低男性甲状腺功能亢进症血清FT3、FT4、T、E2、TG水平,升高TSH水平,临床效果较好。

A Study on the Effect of 131I on the SerumSex Hormones and Thyroglobulin Levels of Male Patients with Hyperthyroidism

Objective:To investigate the effect of 131I on the serum sex hormones and thyroglobulin levels of male patients with hyperthyroidism.Methods:74 cases of male hyperthyroidism patients treated in our hospital were selected and randomly divided into the control group and experimental group with 37 cases in each group. Patients in control group were given oral administration of 20-30 mg/ times, 1 times per day. Patients in the experimental group were given 131I treatment based on the control group. After the end of treatment, the detection and compared between the two groups of patients with serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), testosterone (T) and estradiol (E2), thyroglobulin (TG) level changes and clinical curative effect in detection and compared.Results:Compared with before treatment, the serum FT3, FT4, t, E2, TG levels of both groups were decreased after treatment, the TSH level was significantly increased (P<0.05); compared with the control group, the serum FT3, FT4, t, E2, TG levels were lower, the TSH level and clinical effective rate were higher (P < 0.05).Conclusion:131I could reduce the serum FT3, FT4, T, E2, TG levels of male patients with hyperthyroidism, increased TSH level and had better clinical effect.