自噬在肝脏蛋白质和脂质代谢中的作用

自噬是一个通过降解细胞组分如细胞器和蛋白质等以维持细胞存活和功能的重要的溶酶体途径。肝脏作为新陈代谢的中枢器官,肝脏高度依赖于自噬以发挥正常功能并防止疾病发展。肝细胞自噬的改变参与肝损伤,脂肪肝等肝病的病理变化,以自噬为靶点寻求治疗各种肝病的方法已成为热点研究领域,但自噬在肝脏蛋白质和脂质代谢中的作用极其机制尚不清楚。本文对自噬在肝脏蛋白质和脂质代谢中的作用的最新进展进行综述。

The Effect of Autophagy in Protein and Lipid Metabolismin the Liver

Autophagy is an important lysosomal pathway mediated by degradating cell components such as organelles and proteins to maintain cell function and survival. Liver is highly dependent on autophagy to function properly to prevent disease development. Autophagy participates the occurence of liver injury, fatty liver and et al. Using autophagy to seek the treatment of liver disease has become a focal problem .But the role of autophagy in the metabolism of protein and lipid in liver is unclear. This review summarized the development of autophagy in the metabolismof protein and lipid in liver.